Clinical Microbiome Diagnostics
Clinical Microbiome Diagnostics with IS-pro identifies all bacteria in a sample, whether there is a single species or there are many different bacteria from various taxonomic groups present. Using a metagenomics approach allows circumventing the need of cultivating bacteria and thus limiting the time to a diagnosis from days to hours.
When patients present at a hospital, they are often treated with antibiotics before diagnostic samples are taken, killing many bacteria and making a diagnosis impossible. Moreover, many bacteria in the human body are very difficult to culture even when they are not treated with antibiotics. IS-pro solves these difficulties. Because IS-pro analyses the DNA of bacteria, it can detect uncultivable and antibiotic-treated bacteria just as easily as any other bacterial species.
While other techniques such as next generation sequencing can also detect bacterial DNA in human samples, these techniques are highly complex, laborious and time-consuming and have hardly been standardized for clinical applications. IS-pro solves this problem. A typical workflow of IS-pro takes five hours and can be performed in almost all clinical microbiology laboratories with no need for out-of the ordinary equipment or advanced bioinformatics pipelines.
Currently, IS-pro has been validated for use on a large number of typical clinical samples, such as pus aspirates, synovial fluid, cerebrospinal fluid and various tissue specimens. It has been validated to work with the most commonly used DNA isolation machines and is easy to start up in any lab.
For the near future, IS-pro is being validated for use as a diagnostic and follow-up tool in inflammatory bowel disease, parodontitis, and necrotizing enterocolitis. While many studies are being done by IS-diagnostics in collaboration with various academic and business partners, we also learn from the burgeoning field of research metagenomics and incorporate new insights into our own analyses.